Iron chelators and free radical scavengers are reportedly protective against gentamicin nephrotoxicity. Protective effect of metformin against gentamicin induced nephrotoxicity in rabbits ayesha janjua1, akbar waheed 2 and salman bakhtiar2 1department of pharmacology, foundation university medical college, islamabad, pakistan 2department of pharmacology, army medical college, rawalpindi, pakistan. Due to high relative blood flow the kidney is prone to druginduced damage. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats. Experiments has been done on 77 male wistar rats in weight range of 200 to 250 g. Effect of lycopene and rosmarinic acid on gentamicin. Study of protective effects of stem bark extracts of ficus racemosa in drug induced nephrogenic diabetes insipidus and nephrotoxicity in animal models department of pharmaceutical sciences jjtu page 8 chapter1 introduction 1. How to merge pdfs and combine pdf files adobe acrobat dc. The mechanisms of gentamicin induced nephrotoxicity are not completely known. Combine pdfs and other files word documents, excel spreadsheets, powerpoint ppt files, jpgs, pngs, and more into a single organized pdf thats.
How to prevent, recognize, and treat drug induced nephrotoxicity. Nephrotoxins are the agents displaying nephrotoxicity. There are various agents that exert nephrotoxic effects through different pathogenic mechanisms. The effects of cisplatin induced nephrotoxicity on the pharmacokinetics of a renally excreted antibiotic, gentamicin, were studied in f344 rats. To evaluate histopathological changes of gentamicin induced nephrotoxicity in rabbits receiving the combination of ciprofloxacin and gentamicin compared with rabbits receiving gentamicin alone. Coenzyme q10 and tissue damage mechanism in gm induced nephrotoxicity, in this study, the effects of these two substances for the cotreatment and post treatment on renal injury induced by gentamicin were investigated. Protective effect of bauhinia purpurea on gentamicin.
Combine or merge files into a single pdf, adobe acrobat dc. Drug induced nephrotoxicity and medicinal plants abolfazl khajavi rad,1 reza mohebbati,2 sara hosseinian2 drug induced nephrotoxicity is one of the most common causes of acute kidney injury. Study on the effect of ethanol extract of ipomoea aquatica. Pdf histopathological evaluation of nephroprotective. However its usefulness is limited by signs of nephrotoxicity, which may occur in 30% of treated patients 5. Aminoglycosides are nephrotoxic because a small but sizable proportion of the administered. The nephrotoxic effect develops more in patients who are already suffering from the renal impairment. Sulforaphane sfn, an isothiocyanate naturally occurring in cruciferae, induces cytoprotection in several tissues.
Attenuation of gentamicininduced nephrotoxicity in rats by fleroxacin article pdf available in antimicrobial agents and chemotherapy 416. Phlorizininduced glycosuria does not prevent gentamicin. Table ii shows the baseline clinical and demographic characteristics of the gm and ak groups. The possible protective effects of lycopene lyc and rosmarinic acid ra alone or combined on gentamicin gen induced renal cortical oxidative stress, apoptosis, and. The aim of this study was to compare the nephrotoxic potential of amikacin ak and gentamicin gm in patients with normal baseline renal function. Pdf merger, combine pdf files into one file online. Several natural antioxidants were found to be effective against drug induced toxicity. To evaluate the nephroprotective effect of trichosanthes dioica roxb.
This study aimed to investigate the possible protective effect of apocynin apo on nephrotoxicity induced by gnt in rats. We evaluated the protective effect of dxp on genta induced nephrotoxicity. Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. We included all patients who were treated with gentamicin at our centre over a 1month period. The nephrotoxicity is due to poisonous effect of some toxic chemicals and certain type of drugs on the kidneys. Extracts at the doses 200 and 400 mgkgday for 10 consecutive days, by intraperitoneal route i. Sorrell and collignon showed nephrotoxicity in 4 of 28 patients receiving vancomycin and aminoglycosides compared to 0 of 25 not on the latter. Pdf many drugs can injure the kidneys, but they cause renal injury via only a few common mechanisms. Present study was designed to evaluate the effect of both aqueous and methanolic extracts of cichoriumintybus seeds against gentamicin induced nephrotoxicity in rats model. Pdf on jan 1, 2016, aruna dontabhaktuni and others published gentamicin renal excretion in rats. A free and open source software to merge, split, rotate and extract pages from pdf files. Effect of morin against gentamicininduced nephrotoxicity in young male rats hala a. Aminoglycosideinduced nephrotoxicity is characterised by selectivetargetingoftheproximaltubuleepithelialcellswith in the renal cortex.
This work was conducted to evaluate the possible renoprotective effect of eryngium caucasicum against gentamicin induced renotoxicity. Pdf how to prevent, recognize, and treat druginduced. Protective effect of dexpanthenol on gentamicininduced. A prospective comparative study of gentamicin and amikacin. Androgenandrogen receptor affects gentamicin induced nephrotoxicity through regulation of megalin expression author links open overlay panel elsayed g. Aminoglycosides induced nephrotoxicity and its protection by nigella sativa shahnaz akhtar, mudassara saqib, muniza qayyum, rukhshan khurshid abstract backgound. Nephrotoxic effects of aminoglycosides on the developing. Elsakka a ahmad mohamed elsisi a b osama abd almotaal mansour a bakheet e. Androgenandrogen receptor affects gentamicininduced. Gentamicin and amikacin induced nephrotoxicity was compared based on scr levels figures 1 and 2. Probing strategies to mitigate drug induced nephrotoxicity find, read and cite all the research.
Protective effect of pongamia pinnata flowers against. Combine pdfs in the order you want with the easiest pdf merger available. Nephrotoxicity can be defined as the adverse effect of substances on renal function perazella, 2009. Studies of risk factors for aminoglycoside nephrotoxicity.
However, proposed pathological mechanisms include induction of. Gentamicininduced acute renal failure model creative. Its protective effect has been associated with its ability to induce cytoprotective enzymes through an nrf2dependent pathway. Soda pdf is the solution for users looking to merge multiple files into a single pdf document. It will merge your document files into one and provide you a download link to download merged document. Pdf attenuation of gentamicininduced nephrotoxicity in. The defensive effects of hesperidin hdn, a bioflavonoid was investigated on gentamicin gen provoked nephrotoxicity in rats. We performed a retrospective observational study to examine this and the predictive value of rifle stage on patient outcome in this setting. Aminoglycosides induced nephrotoxicity and its protection. Acute tubular necrosis due to ischemia or other insults and the pathogenesis and potential therapy of aminoglycoside nephrotoxicity are discussed separately. A recent prospective study of hospitalacquired acute renal failure in 2116 patients revealed that 11% of the cases probably were related to aminoglycoside use 2. Application of gentamicin is still related to serious side effects which are reported more often compared to other antibiotics. Aminoglycoside antibiotics, such as gentamicin, can produce nephrotoxicity in dogs, due to in part to an imbalance of pro. Gentamicin nephrotoxicity accounts for 10%15% of all cases of acute renal failure.
The incidence of gentamicin associated acute kidney injury aki as defined by the rifle criteria is unknown. General features of aminoglycoside nephrotoxicity nephrotoxicity induced by aminoglycosides manifests clinically as nonoliguric renal failure, with a slow rise in serum creatinine and a hypoosmolar urinary output developing after several days of treatment. Gentamicin is said to be an effective antibiotic against severe infections, but its major side effect is oxidative nephrotoxicity damage to the kidneys. Drug induced kidney injury is a frequent adverse event which contributes to morbidity and increased healthcare. The kidneys are paired and bean shaped organs, located on either sides of the vertebral. Mechanisms of aminoglycosideinduced nephrotoxicity. The effect of oral calcium load or verapamil on gentamicin. Aminoglycoside nephrotoxicity kidney international.
The aminoglycoside antibiotic gentamicin can cause both ototoxicity and nephrotoxicity, the severity of which varies with circadian time of daily treatment. Approximately 5 % of the administered dose accumulates within these cells after glomerular filtration 2. These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of. Aminoglycosideinduced nephrotoxicity in children pdf. Morin, a bioflavonoid with antioxidant properties, is a constituent of many herbs and fruits that are used as herbal medicines. These agents are freely filtered by the glomeruli and quickly taken up by the proximal tubular epithelial cells, where they are incorporated into lysosomes after first interacting with phospholipids on the brush border membranes.
In order to study the effect of glycosuria on renal gentamicin handling in nondiabetic animals and its possible protective role against gentamicin nephrotoxicity, we induced chronic renal glycosuria with phlorizin, a competitive inhibitor of glucose. Previously we studied the hydrogen peroxide scavenging activity of eryngium caucasicum. No file limit, no ad watermarks a free and beautiful tool to combine your pdf files exactly the way you want it. Studies of risk factors for aminoglycoside nephrotoxicity craig r. Gentamicininduced ototoxicity and nephrotoxicity vary. This free and easy to use online tool allows to combine multiple pdf or images files into a single pdf document without having to install any software. Materials and methods this experimental randomized control trial was conducted from 15th january 2017 to 31st march. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. The major obstacle limiting the use of aminoglycoside, antibiotics has been and continues to be the possibility of drug induced ototoxicity and nephrotoxicity. Nephrotoxicity induced by gentamicin is a complex situation characterized by an increase in blood urea nitrogen bun and serum creatinine concentration, and tubular necrosis.
Nephrotoxic effects of aminoglycosides on the developing kidney samira samieezafarghandy1, johannes n. Androgenandrogen receptor affects gentamicin induced nephrotoxicity through regulation of megalin expression. Lietman, md, phd the epidemiology of aminoglycoside induced nephrotoxicity is not. Study was conducted in the department of histopathology with the collaboration of the department of. A single dose of gentamicin 30 mgkg, iv was given to different groups of rats alone, at the same time as, or on day 4, 7, 15, or 29 following cisplatin administration 6 mgkg, iv. The comparison included both the total dose given, frequency, and single vs. Pdf merge combinejoin pdf files online for free soda pdf. Original article effects of aqueous and methanolic. Specifically, gentamicininduced nephrotoxicity model is mostly used to evaluate in vivo nephroprotective activity of natural compounds. Quickly merge multiple pdf files or part of them into a single one. Protective effect of apocynin against gentamicininduced. Effects of cisplatininduced nephrotoxicity on gentamicin.
Inhibition of megalinmediated endocytosis by statins represents a novel approach to the prevention of aminoglycoside induced nephrotoxicity which is currently being evaluated in. Gentamicin is an important aminoglycoside antibiotic commonly used in treating life threatening gramnegative infections 4. Effects of cosupplementation of vitamins e and c on. Nephrotoxicity was induced in wistar rats by intraperitoneal administration of gentamicin 100 mgkgd for eight days. Effect of concurrent administration of ethanol extract of leaves of bauhinia purpurea and unripe pods of bauhinia purpurea. See pathogenesis and prevention of aminoglycoside nephrotoxicity and ototoxicity. The chronic administration of certain drugs causes nephrotoxicity. Gentamicin gnt is an aminoglycoside antibiotic used for treatment of serious infections, and the nephrotoxic adverse effect is one of the main therapeutic limitations. Effects of pentoxifylline on gentamicininduced nephrotoxicity. Aminoglycoside type antibiotic gentamicin is one of the leading cause of druginduced nephrotoxicity. Protective effect of metformin against gentamicin induced.
In recent years gentamicin nephrotoxicity is significantly reduced by shifting to once daily dosage as well as by eliminating known risk factors. The results showed that dxp ameliorated the renal injury caused by highdose genta by decreasing oxidative stress and the inflammation. You can also sort the file names alphabetically az or za by clicking on the sort buttons located at the right side of the page. Extended interval dosing of aminoglycosides results in a reduction in nephrotoxicity, but its use needs to become more widespread. However, it is not yet resolved if such druginduced adverse effects are independent or dependent phenomena. The development of multidrug resistance among bacteria has now lead clinicians to reexamine the role of the aminoglycosides in the treatment of serious infections. Clinical use of aminoglycosides is restricted by their nephrotoxicity, which is caused by generation of ros 5. In conclusion, sildenafil protects rats against gentamicininduced nephrotoxicity possibly, in part, through its antioxidant activity, inhibition of inos expression, and induction of enos production. Sulforaphane attenuates gentamicininduced nephrotoxicity. Aminoglycosides preferentially affect the proximal tubular cells.
The main concerns with the use of aminoglycoside antibiotics are nephrotoxicity and ototoxicity. Effect of morin against gentamicininduced nephrotoxicity. The study was conducted on rats, and reportedly, for the first time, virgin coconut oil prevented the nephrotoxicity of gentamicin. Nephrotoxicity is a major complication of the gentamicin administration. Inhibitory effect of olive leaf extract on gentamicin.
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